abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：:The interaction between the main components of the new glycopeptide antibiotic teicoplanin, A2-2, A2-3, A2-4, A2-5 and A3-1, and human serum albumin has been studied in vitro by equilibrium dialysis (pH 7.4, 37 degrees C). From Scatchard analysis of the data, the calculated association constants (Ka) were: A2-2, 2.47 ...

journal_title：European journal of clinical pharmacology

authors： Assandri A,Bernareggi A

更新日期：1987-01-01 00:00:00

abstract：:We have assessed the effect of omeprazole on various endocrine functions in man. Eight healthy subjects took 60 mg omeprazole or placebo daily for 1 week in a double-blind, randomized, cross-over study. On Day 7 basal concentrations of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, testostero...

journal_title：European journal of clinical pharmacology

authors： MacGilchrist AJ,Howden CW,Kenyon CJ,Beastall GH,Reid JL

更新日期：1987-01-01 00:00:00

abstract：:The duration of action of tiapamil was assessed in ten patients with stable exertional angina. Maximal symptom-limited treadmill exercise electrocardiography was performed before and at 1, 3, 6 and 9 h after therapy. Significant differences were only found at 1 h after tiapamil with increases in mean exercise duration...

journal_title：European journal of clinical pharmacology

authors： Maltz MB,Davies DW,Caplin JL,Camm AJ

更新日期：1987-01-01 00:00:00

abstract：:We examined the pharmacokinetics of nifedipine after acute and sustained oral therapy and the potential haemodynamic interaction between nifedipine and sublingual nitroglycerin in nine patients with chronic stable angina. Nifedipine pharmacokinetics after a single oral dose and sustained dosing (three times daily for ...

journal_title：European journal of clinical pharmacology

authors： Boje KM,Fung HL,Yoshitomi K,Parker JO

更新日期：1987-01-01 00:00:00

abstract：:The new competitive histamine H2-receptor antagonist, ramixotidine 2 HCl (CM 57755), has been tested in healthy male volunteers for its ability to inhibit pentagastrin-stimulated gastric acid secretion. In the first study, in 8 subjects, pentagastrin 6 micrograms.kg-1 was injected s.c., 90 min after the following 4 or...

journal_title：European journal of clinical pharmacology

authors： Brassinne A,Dresse A,Basilisco G,Manara L

更新日期：1987-01-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a ...

journal_title：European journal of clinical pharmacology

authors： Streete JM,Berry DJ,Newberry JE,Crome P

更新日期：1987-01-01 00:00:00

abstract：:The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous...

journal_title：European journal of clinical pharmacology

authors： Schaaf LJ,Campbell SC,Mayersohn MB,Vagedes T,Perrier DG

更新日期：1987-01-01 00:00:00

abstract：:In a double-blind controlled trial 22 patients with mild or moderate essential hypertension were treated with nicardipine 30 mg t.d.s. and 19 patients with propranolol 80 mg t.d.s. as monotherapy for 24 weeks. Blood pressure in both groups at the end of trial was equally and significantly reduced; systolic pressure 22...

journal_title：European journal of clinical pharmacology

authors： Naukkarinen VA,Karppinen K,Sarna S

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of intravenous enprofylline has been studied in 8 children with asthma. The mean plasma half-life of enprofylline (1.0 h) was considerably shorter than that previously reported in adults. The half-life determined from log urine excretion rate data was identical to the plasma half-life, so urine ex...

journal_title：European journal of clinical pharmacology

authors： Hultqvist C,Borgå O

更新日期：1987-01-01 00:00:00

abstract：:The effect of cimetidine and ranitidine on doxepin pharmacokinetics was studied in 6 healthy volunteers. Each subject completed 3 study phases: Treatment A, 9 consecutive doses of 50 mg doxepin (once daily); Treatment B, same as Treatment A but co-administration of cimetidine 600 mg b.i.d. starting after the sixth dox...

journal_title：European journal of clinical pharmacology

authors： Sutherland DL,Remillard AJ,Haight KR,Brown MA,Old L

更新日期：1987-01-01 00:00:00

abstract：:Some physicians regard patients of Geriatric Units as a homogeneous population with respect to digoxin dosage requirements. Others advocate the use of pharmacokinetic models in prescribing digoxin for the elderly. Sixty in-patients of Geriatric Units were studied and the results compared with those previously obtained...

journal_title：European journal of clinical pharmacology

authors： Dobbs RJ,Royston JP,O'Neill CJ,Deshmukh AA,Nicholson PW,Denham MJ,Dobbs SM

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of enprofylline, a new potent antiasthmatic, has been studied in 20 healthy, elderly subjects, aged 65 to 81 years, and in 7 young adult controls, aged 23 to 37 years. The dose of 1 mg/kg body weight was given as an i.v. infusion. Plasma levels of enprofylline were followed for about 7 h and urine...

journal_title：European journal of clinical pharmacology

authors： Lunell E,Borgå O

更新日期：1987-01-01 00:00:00

abstract：:We have studied the antiaggregatory effect of fenflumizole, a new non-steroidal antiinflammatory imidazole derivative, in ten patients with unstable angina pectoris. We have measured the aggregation induced by arachidonic acid (AA), ADP, and collagen, and serum or plasma concentrations of beta-thromboglobulin (beta-TG...

journal_title：European journal of clinical pharmacology

authors： Grauholt AM,Grande P,Wadt J

更新日期：1987-01-01 00:00:00

abstract：:The duration and extent of cardiac beta-blockade and their relationship to propranolol pharmacokinetics were assessed in nine healthy volunteers. Each subject received 160 mg of regular propranolol (R), 160 mg of sustained-release propranolol (SR) and no drug (control), both as single doses and once daily for 7 days. ...

journal_title：European journal of clinical pharmacology

authors： Lalonde RL,Pieper JA,Straka RJ,Bottorff MB,Mirvis DM

更新日期：1987-01-01 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：:The kinetics of mefloquine were studied in 12 healthy Thai male and 12 healthy Thai female volunteers. Mefloquine (MQ) was administered either alone (750 mg orally) or in combination (MSP) with sulphadoxine (1.5 g) and pyrimethamine (75 mg) to each of 6 male and 6 female subjects. Plasma concentrations of MQ were meas...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Bunnag D,Breckenridge AM,Back DJ

更新日期：1987-01-01 00:00:00

abstract：:Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be com...

journal_title：European journal of clinical pharmacology

authors： Tfelt-Hansen P,Jansen I,Edvinsson L

更新日期：1987-01-01 00:00:00

abstract：:Caffeine metabolites in urine from premature infants were analysed by TLC and HPLC. Caffeine, dimethyluric acids, mono- and dimethylxanthines and, for the first time, a uracil derivative (6-amino-5-[N-methylformylamino]-1,3-dimethyluracil) were identified. ...

journal_title：European journal of clinical pharmacology

authors： Gorodischer R,Zmora E,Ben-Zvi Z,Warszwaski D,Yaari A,Sofer S,Arnaud MJ

更新日期：1986-01-01 00:00:00

abstract：:Ten healthy subjects took single oral doses of placebo, 8.8 +/- 1.8 mg motapizone, 40 +/- 13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5 +/- 1.1 mg prazosin in random order, and, as the last preparation 500 mg acetylsalicylic acid. Thrombocyte aggregation induced "ex-vivo" with collagen, ADP and adrena...

journal_title：European journal of clinical pharmacology

authors： Schulz V,Fischer W,Hanselle U,Huhmann W,Zietsch V

更新日期：1986-01-01 00:00:00

abstract：:The concentration of Torasemide in plasma, dialysate and ultrafiltrate were determined during one haemofiltration and three dialyses. Results show that Torasemide is not significantly eliminated from the blood by these technics. ...

journal_title：European journal of clinical pharmacology

authors： Loute G,Adam A,Ers P,Heremans C,Willems B

更新日期：1986-01-01 00:00:00

abstract：:The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thu...

journal_title：European journal of clinical pharmacology

authors： Mikus G,Ha HR,Vozeh S,Zekorn C,Follath F,Eichelbaum M

更新日期：1986-01-01 00:00:00

abstract：:The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins. Given orally for 5 days, torasemide was clinically very effective and well tolerated. On a weight basis, the diure...

journal_title：European journal of clinical pharmacology

authors： Broekhuysen J,Deger F,Douchamps J,Ducarne H,Herchuelz A

更新日期：1986-01-01 00:00:00

abstract：:A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the met...

journal_title：European journal of clinical pharmacology

authors： Mårtensson J,Denneberg T,Kågedal B

更新日期：1986-01-01 00:00:00

abstract：:Enprofylline 1 mg/kg, a new potent antiasthmatic xanthine derivative, which is mainly eliminated by renal excretion, was given intravenously to 6 normal subjects with and without oral pretreatment with 1 g probenecid. The latter caused a drop in the average total body clearance of enprofylline from 21 to 9.8 l/h, and ...

journal_title：European journal of clinical pharmacology

authors： Borgå O,Larsson R,Lunell E

更新日期：1986-01-01 00:00:00

abstract：:The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

journal_title：European journal of clinical pharmacology

authors： Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

更新日期：1986-01-01 00:00:00

abstract：:The effect of a single dose of carbamazepine (CBZ), 10 mg kg-1, on a battery of simple psychomotor tests was investigated in 12 healthy subjects (6 male, 6 female) in a balanced randomised double blind placebo controlled cross-over study. Psychomotor testing and blood sampling for total and free plasma CBZ, and CBZ 10...

journal_title：European journal of clinical pharmacology

authors： MacPhee GJ,Goldie C,Roulston D,Potter L,Agnew E,Laidlaw J,Brodie MJ

更新日期：1986-01-01 00:00:00

abstract：:The effects of the ingestion of food and digoxin on the cardiovascular system alone and in combination have been observed in eight healthy subjects. A positive inotropic response was seen following food (2.5 MJ) and intravenous digoxin (0.01 mg/kg) with significant decreases in QS2Index (QS2I) pre-ejection period (PEP...

journal_title：European journal of clinical pharmacology

authors： Burgess CD,Crane J

更新日期：1986-01-01 00:00:00

abstract：:Three groups of patients with biliary tract disease treated by cholecystectomy were given ceftriaxone. In Group 1 single doses of 150 mg and 1500 mg were given on Days 1 and 5 after cholecystectomy. In Group 2 2 g was given daily for 6 days and the cholecystectomy was on Day 2. Patients in Group 3 received 2 g every 1...

journal_title：European journal of clinical pharmacology

authors： Hayton WL,Schandlik R,Stoeckel K

更新日期：1986-01-01 00:00:00

abstract：:The gastric inhibitory effects of CM57755, a new histamine H2 receptor antagonist, have been compared in ten healthy male volunteers with the actions of an equal dose of cimetidine and with placebo. The inhibitory effect of CM57755 was virtually identical with, and not significantly different from the effects of cimet...

journal_title：European journal of clinical pharmacology

authors： Wilson JA,Johnston D,Penston J,Wormsley KG

更新日期：1986-01-01 00:00:00

abstract：:A questionnaire survey was carried out to explore differences in the approach to treatment of patients with Type II diabetes between physicians in Northern Ireland, Norway and Sweden, and to discover to what extent it could account for the three-fold difference in drug use between the countries. A representative sampl...

journal_title：European journal of clinical pharmacology

authors： Griffiths K,McDevitt DG,Andrew M,Baksaas I,Helgeland A,Jervell J,Lunde PK,Oydvin K,Agenäs I,Bergman U

更新日期：1986-01-01 00:00:00

abstract：:Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...

journal_title：European journal of clinical pharmacology

authors： Lameire N,Gordts J

更新日期：1986-01-01 00:00:00

abstract：:The kinetics and dynamics of single doses (5 mg p.o.) of the optical isomers of acenocoumarol (R-AC and S-AC) were followed in healthy subjects and the effect on them of cimetidine 800 mg/day was also investigated. The AC enantiomers differed greatly in their pharmacokinetics. The mean residence time (MRT) of R-AC was...

journal_title：European journal of clinical pharmacology

authors： Thijssen HH,Janssen GM,Baars LG

更新日期：1986-01-01 00:00:00

abstract：:17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg Fab fragments of digoxin-specific IgG from sheep. The infusion period ranged between 0.5 and 7 h. Serum and urine concentrations of digoxin bound to Fab fragments, and in 11 cases unbound Fab fragments in serum, were determined d...

journal_title：European journal of clinical pharmacology

authors： Schaumann W,Kaufmann B,Neubert P,Smolarz A

更新日期：1986-01-01 00:00:00

abstract：:Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a...

journal_title：European journal of clinical pharmacology

authors： Schnack C,Röggla G,Luger A,Schernthaner G

更新日期：1986-01-01 00:00:00

abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Lees KR,Reid JL

更新日期：1986-01-01 00:00:00

abstract：:We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjec...

journal_title：European journal of clinical pharmacology

authors： Takabatake T,Ohta H,Yamamoto Y,Ishida Y,Hara H,Nakamura S,Ushiogi Y,Satoh S,Hattori N

更新日期：1986-01-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：:Thirty-eight severely hypertensive patients were treated with oral clonidine. Each patient received a "loading" dose of 0.2 mg clonidine, followed by 0.1 mg hourly until the blood pressure was substantially reduced, or until a total dose of 0.8 mg has been administered. Thirty-five (82.1%) patients responded favourabl...

journal_title：European journal of clinical pharmacology

authors： Karachalios GN

更新日期：1986-01-01 00:00:00